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Loss of fbxl4 disrupts circadian control of sleep by enhancing GABAergic inhibition in arousal-promoting lLNvs

Martinez VD et al

Low levels of SIRT4 produce large amounts of ROS while regulating free fatty acids, which, together with the release of free fatty acids from adipose tissue breakdown, leads to endothelial cell dysfunction, resulting in the development of CAD

In addition, leucine protects against macrophage foam cell formation by inhibiting lipid biosynthesis, promoting cholesterol efflux and enhancing mitochondrial respiration (191, 197, 214, 215)